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Applications & Workflow
The MMI CellCut can be applied in various different research projects:
when the separate analysis of specific subsets of your sample is crucial to obtain relevant and significant data
when the precise and contamination-free isolation of cells from tissue is required.
Typical applications include:
Cancer Research
Oncology
Molecular and Digital Pathology
Stem Cell Research
Neurosciences
Immunology
Plant Research and Crop Science
Forensic Analysis
The MMI CellCut provides a fully auditable and automatically documented workflow:
1. Prepare your sample
The section is placed on the MMI MembraneSlide, a frame slide covered with a thin membrane that is inert and has negligible autofluorescence. Afterwards, the MMI MembraneSlide is inverted and placed onto a glass slide for protection against contamination. Now the sample is sandwiched between the membrane and the glass.
2. Select your cells – any size and flexible shapes
The cells of interest can be selected quickly and easily using the MMI CellTools software. The touch screen enables straightforward selection of one or multiple spots, either using the interactive pen or using the mouse, by freehand or with predefined geometrical shapes. The stage is moving to trace the path drawn while the laser is fixed and focused from below.
3. Excise your cells – automatically and with sub-micron precision
The thin laser cutting path enables a precise and gentle extraction of the selected cell at an outstanding speed.
4. Collect your cells – full visual sample inspection after cutting
The isolated target cell is collected by lowering and lifting of the adhesive MMI IsolationCap held from above. The sample morphology remains 100% intact. After cutting, the sample can be visually inspected on the cap. Just add some buffer and invert the tube to suspend your cells for downstream processing.
Features & Benefits
Precise cutting of various tissue types and even living cells using patented technology
Flexible and quick sample selection, inspection and precise positioning of cut cells by unique and fully auditable Predefined Target Positioning (PTP) feature
Contamination-free and gentle sample capture with 8 different types of MMI collection tubes and MMI MultiCap strips
Fully compatible with downstream analysis employing unstained samples and low damage laser
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